Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CCF0058981 (CCF981) is a 3-chlorophenyl analogue, serving as a noncovalent inhibitor of SARS-CoV-2 3CL pro (SC2), demonstrating potent activity with an IC50 of 68 nM. It also exhibits inhibitory effects against SARS-CoV-1 3CL pro (SC1) with an IC50 of 19 nM, highlighting its antiviral efficacy and potential in COVID-19 research [1].
説明 | CCF0058981 (CCF981) is a 3-chlorophenyl analogue, serving as a noncovalent inhibitor of SARS-CoV-2 3CL pro (SC2), demonstrating potent activity with an IC50 of 68 nM. It also exhibits inhibitory effects against SARS-CoV-1 3CL pro (SC1) with an IC50 of 19 nM, highlighting its antiviral efficacy and potential in COVID-19 research [1]. |
In vitro | CCF0058981 (CCF981) demonstrates inhibition of cytopathic effect (CPE) and plaque reduction in vitro viral replication, with EC50 values of 497 nM and 558 nM, respectively [1]. Additionally, its 50% cytotoxic concentration (CC50) in the CPE antiviral assay exceeds 50 μM [1]. The compound has a half-life (T1/2) of 21.1 minutes and a clearance rate (CLint) of 141 mL/min/kg in human liver microsomes [1]. |
分子量 | 442.9 |
分子式 | C24H19ClN6O |
CAS No. | 2708934-53-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1 mg/mL (2.26 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CCF0058981 2708934-53-4 Microbiology/Virology SARS-CoV CCF 0058981 CCF-0058981 Inhibitor inhibitor inhibit