Powder: -20°C for 3 years | In solvent: -80°C for 1 year
COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 99,000 | |||
10 mg | 在庫あり | ¥ 146,000 | |||
25 mg | 在庫あり | ¥ 226,500 | |||
50 mg | 在庫あり | ¥ 312,500 | |||
100 mg | 在庫あり | ¥ 420,000 | |||
500 mg | 在庫あり | ¥ 844,500 |
説明 | COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice. |
ターゲット&IC50 | COX-2:0.42 μM, COX-1:34.86 μM |
In vitro |
COX-2-IN-34 (compound 8a) (100 μM, 24 h) has no obvious cytotoxicity on RAW264.7 cells.[1] COX-2-IN-34 selectively inhibits COX-1 and COX-2 activities with IC50s of 34.86 and 0.42 μM, respectively. COX-2-IN-34 at 10 μM inhibits COX-2 by 82%.[1] |
In vivo |
COX-2-IN-34 (compound 8a) (50 mg/kg; orally; 3 days; rats) have no gastric ulcer toxicity in a normal male rat model.[1] COX-2-IN-34 (50 mg/kg; s.c.; rats) expressed the reduction of edema claw volume after 0h, 1 h, 2 h, 3h, 4 h, and 6 h of carrageenan injection compared to the control group. Exhibited superior inhibition of 42.90% and 45.95% at the 3rd and 4th hour, respectively, which was comparatively much closer in potency to that of the Celecoxib group (45.18% inhibition of edema at 3h). Showing significant anti-inflammatory effects in the experimental model of carrageenan-induced plantar edema in rats.[1] |
分子量 | 245.23 |
分子式 | C13H11NO4 |
CAS No. | 2788578-71-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (183.5 mM)
You can also refer to dose conversion for different animals. 詳細
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COX-2-IN-34 2788578-71-0 Immunology/Inflammation Neuroscience COX COX2IN34 Inhibitor inhibitor inhibit