store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 38,500 | |||
2 mg | 在庫あり | ¥ 61,000 | |||
5 mg | 在庫あり | ¥ 115,500 | |||
10 mg | 在庫あり | ¥ 156,000 | |||
25 mg | 在庫あり | ¥ 327,000 | |||
50 mg | 在庫あり | ¥ 539,500 | |||
100 mg | 在庫あり | ¥ 817,000 |
説明 | diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
ターゲット&IC50 | STNG (human, PBMCs):130 nM (EC50) |
In vitro | diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon gene (STING) receptor agonists, with EC50 of 130 and 186 nM for humans and mice, respectively. diABZI STING agonist-1 (Tautomerism) at a concentration of 1 μM showed high selectivity for more than 350 kinases tested[1]. |
In vivo | diABZI STING agonist-1 (Tautomerism)(subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type I interferon and proinflammatory cytokines in vivo. diABZI STING agonist-1 (Tautomerism) (intravenous; 3 mg/kg) exhibited systemic exposure with a half-life of 1.4 hours and reached a systemic concentration greater than half the maximum effective concentration of STING in mice (EC50) 200 ng/kg) ml). diABZI STING agonist-1 (Tautomerism) (intravenous; 1.5 mg / kg; 43 days) can significantly inhibit tumor growth and significantly improve survival rate (P <0.001). Eight out of 10 mice are tumor-free[1]. |
別名 | diABZI STING agonist (Compound 3) |
分子量 | 849.94 |
分子式 | C42H51N13O7 |
CAS No. | 2138498-18-5 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1mg/ml (insoluble), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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diABZI STING agonist-1 (Tautomerism) 2138498-18-5 Immunology/Inflammation STING diABZI STING agonist (Compound 3) Compound 3 diABZI STING agonist-1 diABZI STING agonist Tautomerism Inhibitor inhibitor inhibit