Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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2 mg | 在庫あり | ¥ 17,500 | |||
5 mg | 在庫あり | ¥ 28,500 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 86,000 | |||
50 mg | 在庫あり | ¥ 124,500 | |||
100 mg | 在庫あり | ¥ 165,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 31,500 |
説明 | SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens. |
In vitro |
METHODS: Macrophage THP1 were treated with SR-717 (3.6 µM) for 10 min-6 h. The expression levels of target proteins were detected using Western Blot. RESULTS: SR-717 activates p-STING, and its downstream p-TBK1, p-IRF3, p-p65, p-STAT1 and p-STAT3. [1] METHODS: Primary human peripheral blood mononuclear cell PBMCs were treated with SR-717 (10 µM) for 2-6 h. Gene expression levels were detected using RT-qPCR. RESULTS: SR-717 stimulated the activation of IFNB1, CXCL10 and IL6. [1] |
In vivo |
METHODS: To test the antitumor activity in vivo, SR-717 (30 mg/kg) was injected intraperitoneally into WT or Stinggt/gt C57BL/6 mice bearing mouse cutaneous melanoma tumor B16.F10 once daily for seven days. RESULTS: SR-717 inhibited tumor growth as well as prolonged the survival time of mice with rhabdomyosarcoma. The antitumor effect of SR-717 showed an enforced dependence on STING expression, and a lack of activity was observed in Stinggt/gt mice. [1] METHODS: To assay antitumor activity in vivo, SR-717 (10 mg/kg) was administered intravenously three times every two days to C57BL/6 mice harboring mouse cutaneous melanin tumor B16.F10. RESULTS: SR-717 has anti-tumor activity in vivo and prolongs survival. [2] |
分子量 | 351.19 |
分子式 | C15H8F2LiN5O3 |
CAS No. | 2375421-09-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (71.19 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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SR-717 2375421-09-1 Immunology/Inflammation STING immunity MPYS MITA inhibit ISG-THP1 Inhibitor mimetic TMEM173 cGAMP SR717 THP1 antitumor SR 717 ERIS PD-L1 Stimulator of Interferon Genes inhibitor