Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing potential for cancer research applications [1].
説明 | DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing potential for cancer research applications [1]. |
In vitro | DT-6, at concentrations ranging from 0.1-50 μM for 0-18 hours, reduced the protein expression of TGF-β1 in various cell lines, including THP-1, BV2, A549, MCF-7, U87, and HepG2 [1]. Additionally, a 50 μM dose of DT-6 over a 24-hour period decreased the secretion of TGF-β1 in M2 macrophages cultured in conditioned medium (CM) [1]. Furthermore, at 20 μM and 50 μM for 24 and 48 hours, DT-6 inhibited the ability of M2 macrophages to induce epithelial-to-mesenchymal transition (EMT) and the invasive migration of cancer cells by reducing the secretion of TGF-β1 [1]. |
分子量 | 2008.23 |
分子式 | C89H130N20O29S2 |
CAS No. | 2414315-95-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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DT-6 2414315-95-8 Stem Cells TGF-beta/Smad Inhibitor inhibitor inhibit