Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 7,000 | |||
5 mg | 在庫あり | ¥ 10,500 | |||
10 mg | 在庫あり | ¥ 12,500 | |||
25 mg | 在庫あり | ¥ 21,000 | |||
50 mg | 在庫あり | ¥ 38,000 | |||
100 mg | 在庫あり | ¥ 66,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,000 |
説明 | Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. |
In vitro | Kartogenin promotes type I collagen synthesis in dermal fibroblasts by activating the Smad4/Smad5 pathway, without exhibiting significant cytotoxicity on the activity, morphology, and survival of fibroblasts. Additionally, by enhancing the nuclear localization of CBFβ, Kartogenin induces differentiation of hMSCs into chondrocytes and protects articular chondrocytes. |
In vivo | Kartogenin at a concentration of 100 nM stimulates collagen synthesis in the dermis of mice. Additionally, it promotes the growth of skeletal limbs and the development of synovial joints in mice. Concentrations of 10 μM and 100 μM Kartogenin respectively enhance cartilage repair in mouse models of osteoarthritis (OA) induced by collagenase VII and surgically. |
細胞研究 | For the cell viability assay, fibroblasts are seeded on six-well plates, followed by Kartogenin or DMSO treatment. According to the manufacturer's instructions, cell viability and viability are assessed by AlamarBlue assay.(Only for Reference) |
別名 | KGN |
分子量 | 317.34 |
分子式 | C20H15NO3 |
CAS No. | 4727-31-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: <1 mg/mL
DMSO: 63 mg/mL (198.52 mM)
Ethanol: 18 mg/mL (56.72 mM), Heating is recommended.
You can also refer to dose conversion for different animals. 詳細
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Kartogenin 4727-31-5 Stem Cells TGF-beta/Smad Inhibitor stem chondrocytes KGN human differentiation inhibit mesenchymal Transforming growth factor beta cells osteoarthritis inhibitor