Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.
説明 | EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity. |
ターゲット&IC50 | μ opioid receptor:64 nM(Ki), δ opioid receptor:118 nM(Ki) |
In vivo | In CD1 male mice, EST73502 (10-40 mg/kg; p.o.) shows a dose-response analgesic effect reaching a maximum of 64% and an EC50 of 14 mg/kg in the paw pressure test. EST73502 (5 mg/kg; i.p.) attenuated the expression of mechanical allodynia induced by PSNL, reaching a maximal effect of 56%[1]. |
分子量 | 388.88 |
分子式 | C19H27ClF2N2O2 |
CAS No. | 2307458-82-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (128.57 mM)
You can also refer to dose conversion for different animals. 詳細
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EST73502 HCl 2307458-82-6 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor EST73502 EST-73502 Inhibitor inhibitor inhibit