Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 26,000 | |||
25 mg | 在庫あり | ¥ 52,000 | |||
50 mg | 在庫あり | ¥ 84,500 | |||
100 mg | 在庫あり | ¥ 136,000 | |||
500 mg | 在庫あり | ¥ 289,500 |
説明 | EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2]. |
In vitro |
EWP 815 (6, 8 μM; 10 min) inhibits dephosphorylation of [3H]Ins(1,4,5)P3 5-phosphatase in particulate and soluble fractions with IC50s of 6 μM and 8 μM, respectively.[1] EWP 815 (30 μM; 1 h) exerts higher inhibition on Ins(1,4)P2 phosphatase rather than Ins(1,4,5)P3 5-phosphatase with the mean [3H]Ins(1,4)P2/mean [3H]InsP recovery ratio of 2.6.[1] EWP 815 (3-300 μM; 30 min) suppresses thyrotropin-releasing hormone (TRH)-stimulated (100 nM) inositol phospholipid production by 30% (100 μM) and 1.8% (300 μM), respectively, without affecting Ins(1,4,5)P3 binding.[1] |
In vivo | EWP 815 (50 mg/kg; i.p.; 30 min before killed) inhibits the enzyme dopamine β-hydroxylase activity in mice. Reduced the amount of 3 H-α-Me-NA by 12%.[2] |
分子量 | 350.59 |
分子式 | C12H22N4S4 |
CAS No. | 20231-01-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (128.4 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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EWP 815 20231-01-0 Metabolism Phosphatase Hydroxylase Inhibitor inhibitor inhibit