Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 39,500 | |||
25 mg | 在庫あり | ¥ 80,000 | |||
50 mg | 在庫あり | ¥ 120,000 | |||
100 mg | 在庫あり | ¥ 174,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 42,000 |
説明 | PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM). |
ターゲット&IC50 | PTP1B:50 nM |
In vitro | PTP1B-IN-2 extends deep into the active site pocket, forming several hydrogen bonds and hydrophobic interactions with key residues of the catalytic site. PTP1B-IN-2 greatly enhances insulin-mediated IRβ phosphorylation at concentrations of 15 μM and 30 μM. |
キナーゼ試験 | The PTP1B enzymatic assay, the total volume of 100 μL per well contains15 nM recombinant PTP1B protein, 2 mM p-nitrophenylphosphonic acid (pNPP), 1 mM dithiothreitol and 1 mM EDTA (pH 6.5). After 30 min incubation at 37℃, end the reaction by addition of 2.5 M NaOH. The hydrolysis product, pNP, is detected at the absorbance at 405 nm. |
分子量 | 680.79 |
分子式 | C34H36N2O9S2 |
CAS No. | 1919853-46-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (66.1 mM)
You can also refer to dose conversion for different animals. 詳細
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PTP1B-IN-2 1919853-46-5 Metabolism Phosphatase Inhibitor PTP-1B-IN-2 inhibit PTP1BIN2 PTP1B IN 2 inhibitor