Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK-3β inhibitor 3 is a covalent inhibitor (IC50: 6.6 μM) of glycogen synthase kinase 3β (GSK-3β) that is potent, selective, and irreversible.GSK-3β inhibitor 3 can be used to study acute promyelocytic leukemia.
説明 | GSK-3β inhibitor 3 is a covalent inhibitor (IC50: 6.6 μM) of glycogen synthase kinase 3β (GSK-3β) that is potent, selective, and irreversible.GSK-3β inhibitor 3 can be used to study acute promyelocytic leukemia. |
ターゲット&IC50 | GSK-3β:6.6 μM (IC50) |
In vitro |
GSK-3β inhibitor 3 (compound 4-3) (6.25-100 μM; 24-48 h) dose-dependently inhibited the cell viability, with IC50s of 19.56 μM and 26.42 μM in NB4 and NB4-R1 cells at 24 h, respectively. GSK-3β inhibitor 3 (12.5-100 μM; 24 h) significantly increases the percentage of apoptosis in a dose-dependent pattern in NB4 and NB4-R1 cells.[1] GSK-3β inhibitor 3 (100 μM) inhibits GSK-3α activity by 87.3%.[1] |
In vivo |
GSK-3β inhibitor 3 (compound 4-3) (15 mg/kg; a single i.p.; Balb/c female nude mice) shows T1/2 value 14.2 h, AUC values (AUClast=3503.42 ng/mL•h), and maximum concentration (Cmax=515 ng/mL) in mice.[1] GSK-3β inhibitor 3 (15 mg/kg/d; i.p. for 2 weeks; Balb/c female nude mice) inhibits tumor growth of mice by 75.97% relative to vehicle control.[1] |
分子量 | 327.37 |
分子式 | C18H14FNO2S |
CAS No. | 1448990-73-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (687.3 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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GSK-3β inhibitor 3 1448990-73-5 Apoptosis PI3K/Akt/mTOR signaling Stem Cells GSK-3 GSK-3beta inhibitor 3 GSK3β inhibitor 3 GSK 3β inhibitor 3 GSK-3b inhibitor 3 Inhibitor inhibitor inhibit