Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hu7691 free base is an orally active, potent and selective Akt inhibitor with anti-proliferative and neurogenic effects on a variety of neuroblastoma cell lines.Hu7691 free base inhibits Akt1, Akt2, and Akt3 and induces differentiation of neuroblastoma cells.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 67,500 |
5 mg | 在庫あり | ¥ 166,000 |
10 mg | 在庫あり | ¥ 226,500 |
25 mg | 在庫あり | ¥ 349,000 |
50 mg | 在庫あり | ¥ 454,500 |
説明 | Hu7691 free base is an orally active, potent and selective Akt inhibitor with anti-proliferative and neurogenic effects on a variety of neuroblastoma cell lines.Hu7691 free base inhibits Akt1, Akt2, and Akt3 and induces differentiation of neuroblastoma cells. |
ターゲット&IC50 | PKCη:629 nM (IC50), Akt3:28 nM (IC50), ROCK1:354 nM (IC50), p70 S6K:229 nM (IC50), PKA:11 nM (IC50), Akt2:97.5 nM (IC50), Akt1:4.0 nM (IC50), RSK1:756 nM (IC50), AKT1:4.0 nM, AKT2:97.5 nM, AKT3:28 nM, mTOR (p70S6K):229 nM, PKA:11 nM, PKCη:629 nM, ROCK1:354 nM, RSK1:756 nM |
In vitro | In HaCaT cells, Hu7691 free base (2.25, 4.5, 9, 18, 36 μM; 24 hours) effectively induces a decrease in the phosphorylation level of Akt (S473)[1]. |
In vivo | In Balb/c mice (nu/nu, female, 3-4 weeks old, 20-25 g), Hu7691 free base (12.5, 25, 50 mg/kg; oral; once daily for 22 days) exhibited dose-dependent inhibition of tumor growth[1]. |
分子量 | 414.423 |
分子式 | C22H21F3N4O |
CAS No. | 2241232-43-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Hu7691 free base 2241232-43-7 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt Hu-7691 free base Hu7691 Inhibitor inhibitor inhibit