Powder: -20°C for 3 years | In solvent: -80°C for 1 year
iGOT1-01 is an effective inhibitor of glutamate oxaloacetate transaminase 1(GOT1) . iGOT1-01 has IC50s of 84.6 μM and 11.3 μM in GOT1/MDH1 assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 can be used in anti-cancer studies.
説明 | iGOT1-01 is an effective inhibitor of glutamate oxaloacetate transaminase 1(GOT1) . iGOT1-01 has IC50s of 84.6 μM and 11.3 μM in GOT1/MDH1 assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 can be used in anti-cancer studies. |
ターゲット&IC50 | GOT1/MDH1:84.6 μM, GOT1/GLOX/HRP:11.3 μM |
In vitro | iGOT1-01 (3.125-200 μM; for 3 h) reveals little to no toxicity using two readouts of cell viability in PaTu8902 pancreatic and DLD1 colon cancer cells. No inhibitory activity is observed for iGOT1-01 against MDH1 alone at 100 μM[1]. |
In vivo | In female CD1 mice, iGOT1-01 (20 mg/kg; oral) has reasonable bioavailability and exposure properties (t1/2=0.7 hours, Cmax=4133 ng/mL, AUC(0-24 hours)=11734 hour ng/mL)[2]. |
分子量 | 320.39 |
分子式 | C19H20N4O |
CAS No. | 882256-55-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 98 mg/mL (305.88 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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iGOT1-01 882256-55-5 Others GLOX aspartate Inhibitor anti-cancer transaminase inhibit iGOT1 01 GOT1 HRP aminotransferase glutamate iGOT101 MDH oxaloacetate inhibitor