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T76178 |
Aspartate aminotransferase
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Aspartate aminotransferase (AST) is a transaminase enzyme, is often used in biochemical studies. Aspartate aminotransferase catalyzes aspartate and alpha-ketoglutarate converts to oxaloacetate and glutamate. Aspartate am... |
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T78364 |
Alanine aminotransferase
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Endogenous Metabolite
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Alanine aminotransferase (ALT), a pyridoxal-dependent enzyme, catalyzes the reversible interconversion of L-alanine and 2-oxoglutarate into pyruvate and L-glutamate [1]. |
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T8765 |
IGOT1-01
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Others
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iGOT1-01 is an effective inhibitor of glutamate oxaloacetate transaminase 1(GOT1) . iGOT1-01 has IC50s of 84.6 μM and 11.3 μM in GOT1/MDH1 assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 can be used in anti-cancer ... |
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T8648 |
6-AZATHYMINE
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Nucleoside Antimetabolite/Analog
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Influenza Virus
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DNA/RNA Synthesis
,
Antibacterial
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6-azathymine is a potent inhibitors of D-3-aminoisobutyrate-pyruvate aminotransferase. 6-Azauracil acted as a competitive inhibitor with respect to beta-alanine, and was an uncompetitive inhibitor with respect to pyruvic... |
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T8766 |
GOT1 inhibitor-1
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GOT1 inhibitor 2c |
Others
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GOT1 inhibitor-1 (GOT1 inhibitor 2c) is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. |
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T67865 |
BJJF078
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Glutaminase
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BJJF078, an aminopiperidine derivative, is a potent inhibitor of recombinant human and mouse glutamine aminotransferase (TG2) activity, with IC50 values of 41 and 54 nM for human and mouse glutamine aminotransferase, res... |
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T7045 |
Clonidine
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Nexiclon,Catapres,Kapvay |
Adrenergic Receptor
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Clonidine (Kapvay) is a centrally active alpha-adrenergic agonist used predominantly as an antihypertensive agent, usually in combination with other agents. Despite wide-scale use for many years, clonidine has not been l... |
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T26399 |
7-Methyl-6-mercaptopurine
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7-Methyl-6-thiopurine,6-Mercapto-7-methylpurine |
Others
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7-Methyl-6-mercaptopurine (7-Methyl-6-thiopurine) is an inhibitor of PRPP aminotransferase, inhibits IMP metabolism and prevents purine, DNA and RNA synthesis. |
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T67842 |
ERG240
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EGR240 |
Others
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ERG240 is an inhibitor of branched-chain amino acid aminotransferase 1 (BCAT1). ERG240 can be used for the research of rheumatoid arthritis, cancer, and bone disease. |
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T35868 |
BCAT-IN-2
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Others
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BCAT-IN-2 is an orally active and selective inhibitor of mitochondrial branched-chain aminotransferase (BCATm), inhibits BCATm and BCATc, and is used in obesity and dyslipidemia. |
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T0180 |
Benazepril hydrochloride
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CGS 14824A HCl,Benazepril HCl,CGS14824A |
RAAS
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Benazepril hydrochloride (CGS 14824A HCl) is an angiotensin-converting enzyme (ACE) inhibitor widely used in the therapy of hypertension. Benazepril hydrochloride is associated with a low rate of transient serum aminotra... |
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T0805 |
Quinapril hydrochloride
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CI-906,PD-109452-2,Quinapril HCl |
RAAS
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Quinapril hydrochloride (PD-109452-2) is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and congestive heart failure. Quinapril hydrochloride is associated with a low rate of transie... |
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T1356 |
4-Hydroxy-3-methoxybenzylamine hydrochloride
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N-Vanillylamine hydrochloride |
Others
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4-Hydroxy-3-methoxybenzylamine hydrochloride (N-Vanillylamine hydrochloride) is an alkaloid that is an intermediate in the biosynthesis of capsaicin. 4-Hydroxy-3-methoxybenzylamine hydrochloride is produced from vanillin... |
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T2395 |
Vortioxetine
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Lu AA 21004 |
5-HT Receptor
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Serotonin Transporter
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Vortioxetine (Lu AA 21004) is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations during treatment. |
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T1189 |
Milnacipran hydrochloride
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Milnacipran HCl,Savella,Dalcipran |
Serotonin Transporter
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Norepinephrine
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Milnacipran hydrochloride (Savella) is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Milnacipran hydrochloride is an enantiomer of milnacipran, which is used to treat fibromy... |
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T4297 |
Flibanserin
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BIMT-17BS,Girosa,BIMT-17 |
Dopamine Receptor
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5-HT Receptor
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Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n... |
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T0192 |
Levetiracetam
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UCB L059,SIB-S1 |
DNA Methyltransferase
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Others
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Calcium Channel
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Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum... |
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T0083 |
Eplerenone
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Epoxymexrenone,CGP 30083,SC-66110 |
Glucocorticoid Receptor
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Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase ... |
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T0078L |
Lapatinib ditosylate monohydrate
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Lapatinib ditosylate monohydrate,Lapatinib ditoluenesulfonate monohydrate,Lapatinib tosilate hydrate,Lapatinib tosilate,Tykerb,Tyverb |
EGFR
,
Ferroptosis
,
Autophagy
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Lapatinib ditosylate (Lapatinib tosilate) monohydrate is a tyrosine kinase receptor inhibitor used in the therapy of advanced breast cancer and other solid tumors. Lapatinib ditosylate monohydrate therapy is associated w... |
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T0137 |
Mirtazapine
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6-Azamianserin,Org3770 |
Dopamine Receptor
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5-HT Receptor
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Opioid Receptor
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Adrenergic Receptor
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Histamine Receptor
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Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and h... |
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T1951 |
Asenapine Maleate
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Org 5222 maleate,Org 5222 |
5-HT Receptor
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Asenapine Maleate (Org 5222 maleate) is a second generation (atypical) antipsychotic agent that is taken sublingually and used in the treatment of schizophrenia and manic or mixed episodes associated with bipolar 1 disor... |
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T26785 |
BFF122
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BFF 122,BF5,BFF-122 |
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BFF122 is an inhibitor of kynurenine aminotransferase II (KAT II). |
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T27075 |
CPP-115
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CPP-115 is a GABA-aminotransferase inhibitor and a high-affinity vigabatrin analogue. |
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T25288 |
DapL-IN-1
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DapLIN1,DapL-inhibitor-1,DapL inhibitor 1 |
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DapL-IN-1 is a L,L-diaminopimelate aminotransferase (DapL) inhibitor. |
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T68451 |
AG-28262 besylate
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AG-28262 besylate is a VEGFR-2 Inhibitorwhich may affect alanine aminotransferase gene expression and enzymatic activity in the liver. |
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T19364 |
Hydroxypyruvic acid lithium hydrate
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β-Hydroxypyruvic acid lithium hydrate,3-Hydroxypyruvic acid lithium hydrate |
Others
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Hydroxypyruvic acid lithium hydrate is an intermediate in the metabolism of serine, glycine, and threonine. It is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. |
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T78197 |
5-Fluoromethylornithine dihydrochloride
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5-FMOrn dihydrochloride |
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5-Fluoromethylornithine (5-FMOrn) dihydrochloride is a specific, irreversible inhibitor of L-ornithine:2-oxoacid aminotransferase (OAT), utilized in research pertaining to gyrate atrophy of the choroid and retina [1] [2]... |
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T29033 |
U-7524
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2-Aminooxyacetic acid,U 7524,Aminooxyacetic acid,U7524,AOAA |
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U-7524, also known as AOAA and Aminooxyacetic acid, is an inhibitor of 4-aminobutyrate aminotransferase (GABA-T). AOAA is also a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It... |
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TP1496 |
P5 Ligand for Dnak and DnaJ
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p5 Ligand for Dnak and DnaJ is a non-apeptide and correspond to the main binding sites of the 23 residues of the mitochondrial aspartate aminotransferase presequence.P5 ligand is a high affinity ligand for Dnak and DnaJ. |
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T22509 |
3-Methyl-GABA
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Others
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3-Methyl-GABA, an anticonvulsant agent [1] [2], acts as a potent activator of GABA aminotransferase, fits the binding pocket of the GABA A receptor (GABAaR), and activates L-glutamic acid decarboxylase (GAD). |
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T35636 |
SHS4121705
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SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis... |
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T35800 |
MD001
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MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. ... |
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TMIH-0605 |
Vortioxetine-d8 2HBr
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Vortioxetine-d8 2HBr is a deuterated compound of Vortioxetine 2HBr. Vortioxetine 2HBr has a CAS number of 508233-74-7. Vortioxetine is a serotonergic antidepressant used for major depression disorders. Vortioxetine has b... |
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T70990 |
ADMA-d6
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NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synt... |
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T35816 |
ZLY032
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ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and... |
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T36055 |
Nitisinone-13C6
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Nitisinone-13C6 |
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Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyr... |
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T83735 |
Pap12-6 TFA
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Pap12-6, an antibacterial peptide originating from the first twelve N-terminal amino acids of papiliocin found in P. xuthus larvae, exhibits activity against a range of eight Gram-negative bacteria (e.g., E. coli, P. aer... |
