Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 42,500 | |||
10 mg | 在庫あり | ¥ 80,000 | |||
25 mg | 在庫あり | ¥ 135,500 | |||
50 mg | 在庫あり | ¥ 193,500 | |||
100 mg | 在庫あり | ¥ 266,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 37,500 |
説明 | IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway. |
ターゲット&IC50 | IL-4:1.81 µM (EC50) |
In vitro | IL-4-inhibitor-1 exhibits functional disruption of type II IL-4 binding in a cellular context and dose-dependent reduces pSTAT-6 levels (EC50 = 3.1 µM)[1]. |
分子量 | 321.31 |
分子式 | C18H12FN3O2 |
CAS No. | 1332184-63-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 10 mg/mL
DMF: 27.0 mg/mL (84.1 mM)
DMSO:PBS (pH 7.2) (1:5): 0.1 mg/mL
DMSO: 27.0 mg/mL (84.1 mM)
You can also refer to dose conversion for different animals. 詳細
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IL-4-inhibitor-1 1332184-63-0 Immunology/Inflammation IL Receptor IL4inhibitor1 IL 4 inhibitor 1 Inhibitor inhibitor inhibit