Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM). KR-32568 exhibits potent cardioprotective effects. When used at a concentration of 10 μM, it restored cardiac systolic function in an isolated ischemic rat heart model. KR-32568 (0.3 mg/kg) reduced the size of myocardial infarction in a rat model of ischemia and reperfusion injury.
説明 | KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM). KR-32568 exhibits potent cardioprotective effects. When used at a concentration of 10 μM, it restored cardiac systolic function in an isolated ischemic rat heart model. KR-32568 (0.3 mg/kg) reduced the size of myocardial infarction in a rat model of ischemia and reperfusion injury. |
ターゲット&IC50 | NHE1:230 nM |
In vitro | KR-32568 (10 nM-1 μM) inhibited NHE-1-mediated platelet swelling induced by intracellular acidification in rabbit platelet-rich plasma in a concentration-dependent manner with an IC50 value of 24 nM.[1] |
In vivo | KR-32568 (0.1-1.0 mg/kg; i.v.; once) exerts effective cardioprotective effects in rats, such as reducing infarct size and significantly reducing the total number of premature ventricular contractions.[1] |
分子量 | 261.25 |
分子式 | C13H12FN3O2 |
CAS No. | 852146-73-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (344.5 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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KR-32568 852146-73-7 Membrane transporter/Ion channel Sodium Channel KR 32568 KR32568 Inhibitor inhibitor inhibit