Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 15,000 | |||
5 mg | 在庫あり | ¥ 34,500 | |||
10 mg | 在庫あり | ¥ 50,000 | |||
25 mg | 在庫あり | ¥ 85,000 | |||
50 mg | 在庫あり | ¥ 126,000 | |||
100 mg | 在庫あり | ¥ 181,000 | |||
500 mg | お問い合わせ | ¥ 374,000 |
説明 | 3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations. |
In vitro | Expression of TRAIL-mediated apoptosis signaling-related death receptor DR5 was increased in 3-O-acetyloleanolic acid-treated HCT-116 cells. Activation of caspase-8 and caspase-3, critical mediators of extrinsic apoptosis signaling, was also increased by 3-O-acetyloleanolic acid. 3-O-acetyloleanolic acid induces apoptosis in HCT-116 cells mediated by an extrinsic apoptosis signaling cascade via up-regulation of DR5. |
細胞研究 | Modulation of phosphatidylserine externalization during apoptosis was measured using annexin V conjugated with the fluorescent dye fluorescein isothiocyanate (FITC). The HCT-116 cells were seeded onto 6-well plates at a density of 3*10^5 cells/well. After treatment with 25 uM 3-O-acetyloleanolic acid for 6 h, the cells were stained with the annexin V-FITC conjugate, and then imaged at a^40 objective magnification using a confocal laser scanning microscope. |
植物由来 |
分子量 | 498.74 |
分子式 | C32H50O4 |
CAS No. | 4339-72-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.5 mg/mL (5.01 mM)
You can also refer to dose conversion for different animals. 詳細
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3-O-Acetyloleanolic acid 4339-72-4 Apoptosis 3 O Acetyloleanolic acid 3-O-Acetyloleanolic acid Inhibitor inhibit 3OAcetyloleanolic acid inhibitor