Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt signaling pathway.Miclxin induces β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 22,000 | |||
5 mg | 在庫あり | ¥ 55,000 | |||
10 mg | 在庫あり | ¥ 91,000 | |||
25 mg | 在庫あり | ¥ 158,500 | |||
50 mg | 在庫あり | ¥ 225,000 | |||
100 mg | 在庫あり | ¥ 303,000 | |||
500 mg | 在庫あり | ¥ 608,500 |
説明 | Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt signaling pathway.Miclxin induces β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60. |
In vitro | Miclxin (0-15 μM; 48 h) inhibits the growth of β-catenin mutant HCT116 cells and isogenic HCT116 cells (CTNNB1 Δ45/-), and (10 μM; 24 h) induces apoptosis in HCT116 cells.[1] |
別名 | DS37262926 |
分子量 | 441.52 |
分子式 | C26H27N5O2 |
CAS No. | 2494198-61-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (113.25 mM)
You can also refer to dose conversion for different animals. 詳細
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Miclxin 2494198-61-5 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin DS 37262926 DS-37262926 DS37262926 Inhibitor inhibitor inhibit