Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and hampers the formation of new viroplasms.
説明 | ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and hampers the formation of new viroplasms. |
In vitro | ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest. The combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis[1]. ML-60218 interferes with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage[2]. |
分子量 | 452.38 |
分子式 | C19H15Cl2N3O2S2 |
CAS No. | 577784-91-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (210.00 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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ML-60218 577784-91-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis ML60218 transcription inhibit broad-spectrum ML 60218 Inhibitor viroplasms yeast inhibitor