Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPHA (MMP-2/MMP-9 Inhibitor II) is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, >1000 and 795 nM, respectively).BPHA has anti-angiogenic and BPHA has anti-angiogenic and anti-tumor activities.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 49,500 |
5 mg | 在庫あり | ¥ 136,000 |
10 mg | 在庫あり | ¥ 195,000 |
25 mg | 在庫あり | ¥ 296,000 |
50 mg | 在庫あり | ¥ 397,000 |
100 mg | 在庫あり | ¥ 535,000 |
500 mg | 在庫あり | ¥ 1,076,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 140,500 |
説明 | BPHA (MMP-2/MMP-9 Inhibitor II) is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, >1000 and 795 nM, respectively).BPHA has anti-angiogenic and BPHA has anti-angiogenic and anti-tumor activities. |
ターゲット&IC50 | MMP2:12 nM, MMP9:16 nM, MMP14:17 nM, MMP1:974 nM, MMP3:>1000 nM, MMP7:795 nM |
In vivo | Administration of BPHA (200 mg/kg; via oral; daily) in mice effectively suppresses tumor-induced angiogenesis, primary tumor growth, and liver metastasis. BPHA exhibits remarkable growth inhibitory activity of 48% and 45% in the B16-BL6 melanoma and F2 hemangio-endothelioma models, respectively.[1] |
別名 | MMP-2/MMP-9 Inhibitor II |
分子量 | 396.46 |
分子式 | C21H20N2O4S |
CAS No. | 193807-60-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methanol: 22.5 mg/mL (56.8 mM)
DMSO: 90.0 mg/mL (227.0 mM)
You can also refer to dose conversion for different animals. 詳細
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BPHA 193807-60-2 Proteases/Proteasome MMP MMP-2/MMP-9 Inhibitor II Inhibitor inhibitor inhibit