Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively.OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 23,000 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 91,000 | |||
25 mg | 在庫あり | ¥ 181,000 | |||
50 mg | 在庫あり | ¥ 271,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively.OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung cancer. |
ターゲット&IC50 | A549 cells:1004 nM, H23:431 nM, H1703:145 nM, EBC-1:172 nM, H1975 (EGFR):118 nM |
In vitro | OTUB1/USP8-IN-1 (10 nM-10 μM; 72 hours) inhibited the proliferation of H1975, H1703, EBC-1, H23, and A549 cells with IC50 values of 118, 145, 172, 431, and 1004 nM, respectively[1]. |
In vivo | OTUB1/USP8-IN-1 (5 mg/kg; intraperitoneal injection; QD and BID, for 2 weeks) reduced the total tumor weight and average tumor volume in BALB/c nude mice by over twofold with BID dosing[1]. |
分子量 | 426.83 |
分子式 | C22H16ClFN2O4 |
CAS No. | 2858800-98-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (70.29 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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OTUB1/USP8-IN-1 2858800-98-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB Inhibitor inhibitor inhibit