Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-6776 is a selective USP7 inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 17,000 | |||
5 mg | 在庫あり | ¥ 41,000 | |||
10 mg | 在庫あり | ¥ 66,000 | |||
25 mg | 在庫あり | ¥ 127,000 | |||
50 mg | 在庫あり | ¥ 182,000 | |||
100 mg | お問い合わせ | ¥ 248,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 45,500 |
説明 | GNE-6776 is a selective USP7 inhibitor. |
In vitro | GNE-6776 non-covalently targets USP7 12?? distant from the catalytic cysteine. GNE-6776 attenuates ubiquitin binding and thus inhibits USP7 deubiquitinase activity. GNE-6776 interacts with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways.GNE-6776 selectively inhibits recombinant USP7 relative to 36 other deubiquitinases. GNE-6776 remains selective even at 100?μM, a more than sixfold higher concentration than used in cellular assays. GNE-6776 significantly inhibits USP7 while remaining selective against 44-47 other detected deubiquitinases. |
In vivo | Although efficacious exposure is only transiently achieved, GNE-6776 causes modest, although significant, EOL-1 xenograft growth delay. |
別名 | GEN6776 |
分子量 | 348.4 |
分子式 | C20H20N4O2 |
CAS No. | 2009273-71-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 310 mg/mL
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GNE-6776 2009273-71-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB GEN-6776 Deubiquitinase DUBs GEN 6776 Inhibitor GEN6776 inhibit GNE 6776 GNE6776 inhibitor