Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamostat HCl is used in the study of acute pancreatitis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 107,000 | |||
10 mg | 在庫あり | ¥ 156,000 | |||
25 mg | 在庫あり | ¥ 245,500 | |||
50 mg | 在庫あり | ¥ 328,500 | |||
100 mg | 在庫あり | ¥ 443,000 |
説明 | Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamostat HCl is used in the study of acute pancreatitis. |
ターゲット&IC50 | Thrombin:1.9 μM, Plasmin:950 nM, Trypsin:39 nM |
In vivo | In rats or rabbits, Patamostat (intravenous infusion) at doses of 0.03-0.3 mg/kg or 0.3-3.0 mg/kg, respectively, reduces mortality after the induction of pancreatitis in a dose-dependent manner[1].In dogs with pancreatitis, Patamostat (intravenous infusion) at doses of 1.0-3.0 mg/kg reduces the increases of serum trypsin and lipase activities[1].In male Wistar rats, continuous infusion of Patamostat (2 mg/kg per h) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme[2]. |
別名 | Patamostat HCl(114568-26-2 Free base) |
分子量 | 448.92 |
分子式 | C20H21ClN4O4S |
CAS No. | 3031765-17-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Patamostat HCl 3031765-17-7 Proteases/Proteasome Serine Protease Protease Patamostat HCl(114568-26-2 Free base) 114568-26-2 Free base 114568-26-2 Inhibitor inhibitor inhibit