Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 29,500 | |||
10 mg | 在庫あり | ¥ 49,000 | |||
25 mg | 在庫あり | ¥ 82,500 | |||
50 mg | 在庫あり | ¥ 123,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 28,500 |
説明 | Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells. |
ターゲット&IC50 | Trypsin:3.0 μM |
In vitro | demethylwedelolactone (DWEL) inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells.DWEL reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells.?Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice.?DWEL derivatives exert anti-invasive growth effect on breast cancer cells. |
植物由来 |
分子量 | 300.22 |
分子式 | C15H8O7 |
CAS No. | 6468-55-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (74.95 mM)
You can also refer to dose conversion for different animals. 詳細
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Demethylwedelolactone 6468-55-9 Proteases/Proteasome Serine Protease Inhibitor inhibit Ser/Thr Protease Serine proteases Threonine proteases Serine endopeptidases inhibitor