Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PHY34 is a late stage autophagy inhibitor with nanomolar level inhibitory effect and anti-tumor activity against high-grade serous ovarian cancer (HGSOC) in vivo.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 38,500 | |||
2 mg | 在庫あり | ¥ 57,000 | |||
5 mg | 在庫あり | ¥ 89,500 | |||
10 mg | 在庫あり | ¥ 132,500 | |||
25 mg | 在庫あり | ¥ 212,500 | |||
50 mg | 在庫あり | ¥ 289,500 | |||
100 mg | 在庫あり | ¥ 385,500 | |||
500 mg | 在庫あり | ¥ 776,000 |
説明 | PHY34 is a late stage autophagy inhibitor with nanomolar level inhibitory effect and anti-tumor activity against high-grade serous ovarian cancer (HGSOC) in vivo. |
In vitro | In HGSOC cell lines, PHY34 showed cytotoxicity with IC50 of 4 nM. Its IC50 values in MDA-MB-435 and MDAMB-231 cell lines were 23 nM and 5.2 nM, respectively. In OVCAR3 cells, 100 nM PHY34 increased the level of early and late apoptotic cells [1]. |
In vivo | In the hollow fiber deflector, PHY34 significantly inhibited the growth of cancer cells; In the transplanted tumor model, PHY34 reduced the ovarian tumor load. The bioavailability of mice was 56.6% after intravenous injection of 0.6 mg/kg, intraperitoneal injection of 1.8 mg/kg or oral administration of 75 mg/kg PHY34, and 2.5% after oral administration. After oral administration, the systemic clearance (CL) was 194.1 L/hr/kg, which was nearly 40 times the liver blood flow of mice, indicating that PHY34 had significant extrahepatic clearance. After oral administration, PHY34 was rapidly absorbed, and Tmax was 0.25 hr [1]. |
分子量 | 582.55 |
分子式 | C30H30O12 |
CAS No. | 2130033-55-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 30 mg/mL
DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL
DMSO: 90mg/mL (154.5mM)
Ethanol: 10 mg/mL
You can also refer to dose conversion for different animals. 詳細
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PHY34 2130033-55-3 Autophagy PHY 34 PHY-34 Inhibitor inhibitor inhibit