Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
説明 | NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1). |
In vitro | NBDHEX not only is cytotoxic toward the parental small cell lung cancer H69 cell line (LC(50) of 2.3 +/- 0.6 micromol/L) but also overcomes the multidrug resistance of its variant, H69AR, which overexpresses the ATP-binding cassette transporter multidrug resistance-associated protein 1 (MRP1;?LC(50) of 4.5 +/- 0.9 micromol/L).?Drug efflux experiments, done in the presence of a specific inhibitor of MRP1, confirmed that NBDHEX is not a substrate for this export pump [1]. |
In vivo | NBDHEX, In female mice, treatment results in a statistically significant tumour inhibition (approximately 70%) [1]. |
分子量 | 297.33 |
分子式 | C12H15N3O4S |
CAS No. | 787634-60-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (420.41 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
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