Powder: -20°C for 3 years | In solvent: -80°C for 1 year
QL-X-138 HCl is a novel selective and highly potent BTK/MNK dual-kinase inhibitor with anticancer activity that binds covalently to BTK and noncovalently to MNK. QL-X-138 HCl inhibited BTK, MNK1, and MNK2 kinases. QL-X-138 HCl has anti-dengue virus 2 activity and shows anti-proliferative activity in acute myeloid leukemia cells. QL-X-138 HCl can be used to study lymphoma and leukemia.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 111,000 | |||
10 mg | 在庫あり | ¥ 159,000 | |||
25 mg | 在庫あり | ¥ 248,000 | |||
50 mg | 在庫あり | ¥ 342,000 |
説明 | QL-X-138 HCl is a novel selective and highly potent BTK/MNK dual-kinase inhibitor with anticancer activity that binds covalently to BTK and noncovalently to MNK. QL-X-138 HCl inhibited BTK, MNK1, and MNK2 kinases. QL-X-138 HCl has anti-dengue virus 2 activity and shows anti-proliferative activity in acute myeloid leukemia cells. QL-X-138 HCl can be used to study lymphoma and leukemia. |
ターゲット&IC50 | BTK Y223:11 nM (EC50), PLCγ2 Y1217:57 nM (EC50) |
In vitro | In Ramos, OCI-AML3, U2932, TMD8, and U937 cells, QL-X-138 HCl(3-10000 nM; 4 hours) significantly inhibited the auto-phosphorylation of BTK Y223 (EC50=11 nM).QL-X-138 HCl strongly blocked the phosphorylation of the BTK downstream target PLCγ2 Y1217 (EC50=57 nM) and suppressed the phosphorylation of the MNK downstream target eIF4E S209 at a concentration of 1 μM[1]. |
別名 | QL-X-138 HCl(1469988-63-3 Free base) |
分子量 | 457.91 |
分子式 | C25H20ClN5O2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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QL-X-138 HCl Angiogenesis MAPK Tyrosine Kinase/Adaptors MNK BTK QL-X-138 HCl(1469988-63-3 Free base) Inhibitor inhibitor inhibit