Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | お問い合わせ | ¥ 30,500 |
5 mg | お問い合わせ | ¥ 69,500 |
10 mg | お問い合わせ | ¥ 102,500 |
25 mg | お問い合わせ | ¥ 169,500 |
50 mg | お問い合わせ | ¥ 226,500 |
100 mg | お問い合わせ | ¥ 317,000 |
説明 | AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). |
ターゲット&IC50 | FLT3:302 nM , FAK:995 nM , FES:449 nM , PYK2:2288 nM , Ack1:156 nM , INSR:1256 nM , BLK:977 nM , ALK:420 nM , Brk:843 nM , MNK2:228 nM , MLK1:88 nM , FLT4:1784 nM , IGF-1R:1.6 μM , ERB4:195 nM , TEC:1317 nM , IRR:840 nM |
In vitro | AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM). |
分子量 | 485.58 |
分子式 | C27H31N7O2 |
CAS No. | 1421373-99-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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AZ7550 1421373-99-0 Angiogenesis Cytoskeletal Signaling JAK/STAT signaling MAPK Metabolism Tyrosine Kinase/Adaptors Tyrosine Kinases IGF-1R PYK2 MNK MLK FAK EGFR FLT ACK ALK BTK Drug Metabolite Epidermal growth factor receptor inhibit Inhibitor ErbB-1 HER1 AZ 7550 AZ-7550 inhibitor