Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 85,500 | |||
10 mg | 在庫あり | ¥ 152,500 | |||
25 mg | 在庫あり | ¥ 294,000 | |||
50 mg | 在庫あり | ¥ 402,000 | |||
100 mg | 在庫あり | ¥ 544,000 |
説明 | Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS). |
ターゲット&IC50 | 5-HT4 receptor:115 nM (Ki) |
In vitro | Renzapride was selective for serotonergic receptors and, in particular, had high affinity for human 5-HT(3) and guinea-pig 5-HT(4) receptors (K(i) 17 and 477 nm, respectively)[1]. |
In vivo | Renzapride(BRL 24924)(0.5-1 mg/kg) and another 5-HT1P antagonist, N-acetyl-5-hydroxytryptamine-5-hydroxytryptamine amide (5 mg/kg), significantly increased the rate of emptying of 51Cr-labeled liquid meals from the mouse stomach[2]. |
別名 | BRL 24924 |
分子量 | 323.82 |
分子式 | C16H22ClN3O2 |
CAS No. | 112727-80-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (30.88 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Renzapride 112727-80-7 GPCR/G Protein Neuroscience 5-HT Receptor BRL-24924 BRL24924 BRL 24924 Inhibitor inhibitor inhibit