Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity. It is employed in researching rheumatoid arthritis and psoriasis [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | お問い合わせ | ¥ 406,500 |
50 mg | お問い合わせ | ¥ 822,000 |
100 mg | お問い合わせ | ¥ 1,124,500 |
説明 | RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity. It is employed in researching rheumatoid arthritis and psoriasis [1]. |
In vivo | RORγt inverse agonist 14 (8e) demonstrates a half-life (t 1/2) of 11 hours following an intravenous (iv) injection at a dosage of 1 mg/kg. When administered orally at 4 mg/kg in mice, this compound achieves a peak concentration (t max) in 2 hours, with an oral bioavailability (%F) of 101 [1]. Additionally, dosages ranging from 5 to 20 mg/kg of RORγt inverse agonist 14 (8e) are comparably effective in reducing arthritic scores to those observed with a murine analog of the commercially available TNF decoy receptor, etanercept [1]. |
分子量 | 678.61 |
分子式 | C26H26F8N2O6S2 |
CAS No. | 2672496-70-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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RORγt inverse agonist 14 2672496-70-5 Metabolism ROR Inhibitor inhibitor inhibit