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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T24727 | ROR Modulator I | ROR-Modulator-I,RORModulatorI | |
ROR Modulator I is the first potent inverse agonist of the retinoid-related orphan receptor. It also has dual selectivity for RORβ and RORγt. | |||
T12750 | ROR agonist-1 | Others | |
ROR agonist-1 is a potent and orally bioavailable the retinoic acid receptor-related orphan receptor C2 (RORC2) inverse agonist(inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5). | |||
T4050 | GSK2981278 | ROR gama modulator 1 | ROR |
GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). | |||
T39250 | Bevurogant | ROR | |
Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases. | |||
TQ0007 | Cintirorgon | LYC-55716 | ROR |
Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells. | |||
T4670 | SR0987 | ROR | |
SR0987 is a RORγt agonist, | |||
T5163 | SR1001 | ROR | |
SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM). | |||
T4594 | SR1078 | SR 1078 | ROR |
SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ. | |||
T7388 | GSK805 | ROR | |
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA bindi... | |||
T9635 | Cedirogant | ABBV-157 | ROR |
Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study. | |||
T16832 | S18-000003 | ROR | |
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production. | |||
T12753 | RORγt Inverse agonist 6 | ROR | |
T9623 | RORγt inverse agonist 13 | ROR | |
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1]. | |||
T14369 | AZD-0284 | ROR | |
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1]. | |||
T5160 | SR3335 | ML 176 | ROR |
SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM). | |||
T6690 | T0901317 | Apoptosis , FXR , Liver X Receptor , ROR | |
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB). | |||
T12010 | Aurora B inhibitor 1 | Aurora Kinase | |
T9040 | Aurora kinase inhibitor-2 | IUN-70219,Aurora Kinase Inhibitor II | Aurora Kinase |
Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M). | |||
T61093 | MicroRNA-21-IN-2 | Others | |
MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer. | |||
T67943 | RORγ inverse agonist 1 | ||
RORγ inverse agonist 1 has anti-inflammatory activity and can be used to treat rheumatism and psoriasis. | |||
T5520 | Cetrorelix Acetate | Cetrorelix | GNRH Receptor |
Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. | |||
T5520L | Cetrorelix diacetate | NS-75A,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate | GNRH Receptor |
Cetrorelix diacetate (NS-75A) is is a gonadotropin-releasing hormone antagonist. It works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of luteinizing hormone (LH) ... | |||
T18977 | Dihydrorhodamine 123 | DHR 123 | Others |
Dihydrorhodamine 123 (DHR 123) is a fluorescent probe (λex=488 nm, λem=525 nm). | |||
T5524 | Aurora kinase inhibitor-3 | Aurora Kinase Inhibitor III | Aurora Kinase |
Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR. | |||
T11013L1 | Dextrorotation nimorazole phosphate ester TFA | Others | |
Dextrorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent. | |||
TQ0007L | Cintirorgon sodium | LYC-55716 sodium salt,LYC 55716,LYC55716 | |
Cintirorgon (LYC-55716) is an orally active RORgamma agonist with potential immunomodulatory and antineoplastic activities. LYC-55716 selectively binds to the RORg, and binds to ROR response elements, enhancing the funct... | |||
T64146 | RORγt/DHODH-IN-3 | ||
RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 has significant in vivo anti-inflammatory effects. | |||
T64145 | RORγt/DHODH-IN-1 | ||
RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant in vivo anti-inflammatory effects. | |||
T63609 | RORγt modulator 3 | ||
RORγt modulator 3 is a modulator of retinol-related orphan receptor γt (RORγt) and can be used to study RORγt-mediated diseases such as pain, COPD, inflammation, asthma, colitis, multiple sclerosis, rheumatoid arthritis,... | |||
T62647 | Aurora A inhibitor 2 | ||
Aurora A inhibitor 2 (Compound 16h) is a potent inhibitor of Aurora A kinase (IC50: 21.94 nM). | |||
T63853 | Aurora kinase inhibitor-10 | ||
Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects. | |||
T70309 | Dicetrorelix pamoate | ||
Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH)... | |||
T72252 | RORγt inverse agonist 14 | ROR | |
RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity. It is employed in researching rheumatoid arthritis and psoriasis [1]. | |||
T63124 | RORγt modulator 4 | ||
RORγt modulator 4 is a RORγt modulator that regulates IL-17A production activity in cells derived from mouse spleen. | |||
T79470 | RORγt inverse agonist 31 | ROR | |
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (IC50) of 0.428 μM. It has demonstrated efficacy in mitigatin... | |||
T68765 | Spirorenone | ||
Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I... | |||
T25300 | Dehydrorotenone | ||
Dehydrorotenone is a retinoid of Tephrosia egregia and has great antioxidant activity. | |||
T63436 | Aurora A inhibitor 1 | ||
Aurora A inhibitor 1 is a potent and selective Aurora A inhibitor. Aurora A is associated with cancers of multiple histological origins and may exhibit oncogenic activity when overexpressed. aurora A inhibitor 1 exhibits... | |||
T39363 | 2,4-Difluororesorcinol | ||
2,4-Difluororesorcinol is a fluorinated building block. | |||
T125443 | Physarorubinic acid A | ||
Physarorubinic acid A is a useful organic compound for research related to life sciences and the catalog number is T125443. | |||
T10412 | Aurora inhibitor 1 | Aurora Kinase | |
Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase). | |||
T62484 | Aurora Kinases-IN-2 | ||
Aurora Kinases-IN-2 (compound 12Aj) is a potent inhibitor of Aurora kinases, acting on Aurora A (IC50: 90 nM) and Aurora B (IC50: 152 nM). Aurora Kinases-IN-2 can be used in cancer research. | |||
T63678 | RORγt modulator 2 | ||
RORγt modulator 2 is a modulator of retinol-related orphan receptor γt (RORyt) (IC50<50 nM) and can be used in the study of RORγt-mediated diseases such as pain, inflammation, asthma, rheumatoid arthritis, COPD, multiple... | |||
T12752 | RORγt Inverse agonist 3 | Others | |
RORγt Inverse agonist 3 is a potent, selective and orally active inverse agonist of RORγ(EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively). | |||
T12755 | RORγt Inverse agonist 2 | Others | |
RORγt Inverse agonist 2 is a selective, orally active inverse agonist of RORγt(EC50 of 119 nM). | |||
T72254 | RORγt inverse agonist 26 | ||
RORγt inverse agonist 26, a potent reverse agonist of RORγt, effectively modulates Th17 cell differentiation and suppresses IL-17 production. This compound shows promising potential for researching inflammation and autoi... | |||
T64140 | RORγt agonist 2 | ||
RORγt agonist 2 is a potent agonist of RORγt. RORγt agonist 2 induces Th17 cell differentiation, increases levels of pro-inflammatory cytokines and thus enhances lymphocyte cytotoxicity. rorγt agonist 2 exhibits an inhib... | |||
T40043 | RORγt Inverse agonist 10 | ||
RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectivel... | |||
T131596 | Dihydrorobustic deoxybenzoin | ||
Dihydrorobustic deoxybenzoin is a useful organic compound for research related to life sciences and the catalog number is T131596. | |||
T82931 | Aurora A inhibitor 3 | Aurora Kinase | |
Aurora A Inhibitor 3 (Compound 5h) effectively inhibits Aurora-A kinase, exhibiting an IC50 of 0.78 μM, and demonstrates cytotoxicity against MCF-7 and MDA-MB-231 cell lines with GI50 values of 0.12 μM and 0.63 μM, respe... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T3S1251 | Neoruscogenin | ROR | |
1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors. | |||
T2834 | Nobiletin | Hexamethoxyflavone | Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy |
Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic... | |||
T1079 | Metronidazole | Flagyl,Metronidazol,Anagiardil | Apoptosis , NADPH , Hydrogenase , Antibacterial , Antibiotic , Parasite , Antifection |
Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. | |||
T13502 | 3-Oxo-5β-cholanoic acid | Dehydrolithocholic acid | ROR |
T37009 | Oxychlororaphine | phenazine-1-carboxamide | Antibacterial |
Oxychlororaphine (phenazine-1-carboxamide) inhibits strongly the growth of Streptomyces sp. 441. | |||
T4912 | Jatrorrhizine chloride | Yatrorhizine chloride,Neprotine chloride | Others , 5-HT Receptor , OCT , Antibacterial , AChE |
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h... | |||
T3840 | Dihydroresveratrol | 3,4',5-Trihydroxybibenzyl | Estrogen Receptor/ERR , Others |
Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota. Dihydroresveratrol and dihydroresveratrol monosulfate are ... | |||
TN1586 | Dihydrorotenone | Apoptosis , Mitochondrial Metabolism | |
Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. | |||
T3933 | Jatrorrhizine | Yatrorizine,neprotin | MAO , 5-HT Receptor , Antibacterial , AChE |
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo... | |||
T2986 | Jatrorrhizine hydrochloride | Others | |
Jatrorrhizine hydrochloride is extracted from berberidis, radix. | |||
T34389 | Rorifone | 10-(Methylsulfonyl)decanenitrile | |
Rorifone is a biochemical. | |||
TN6425 | Saprorthoquinone | ||
Saprorthoquinone is a natural product from Salvia prionitis. | |||
TN1360 | Afrormosine | Others | |
Afrormosine is a natural product | |||
TN2147 | Retrorsine | P450 , OCT | |
Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury. | |||
T75436 | Jatrorrhizine hydroxide | ||
Jatrorrhizine hydroxide, an alkaloid derived from Coptis chinensis, exhibits a range of biological activities including neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties [1]. It acts as a potent ... | |||
TN3864 | Dihydroresveratrol 3-O-glucoside | Others | |
Dihydroresveratrol 3-O-glucoside is a natural product fonud in the leaves of Camellia sinensis var. assamica (J.W. Mast.) Kitam. | |||
T80004 | Tetrahydrorhombifoline | ||
Tetrahydrorhombifoline, a quinolizidine alkaloid found in the aerial parts of Genista vuralii A. Duran & H. Dural (Fabaceae), exhibits antibacterial and antifungal activities as evidenced by the extract from G. vuralii [... | |||
T41264 | Roridin L2 | ||
Roridin L2 is a natural product for research related to life sciences. The catalog number is T41264 and the CAS number is 85124-22-7. | |||
T32198 | Retrorsine N-oxide | Isatidine | |
Isatidine is a pyrrolizidine alkaoid. | |||
TMA0600 | Dihydrorobinetin | Others | |
(+)-Dihydrorobinetin is reported as a chemical marker of vinegars aged in acacia wood and can be used for authenticity purposes. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPK-00413 | ROR1 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi) | Human,Cynomolgus,Rhesus | HEK293 Cells |
ROR1 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 44.9 kDa and the accession number is Q01973-1. | |||
TMPK-00572 | ROR1 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells |
ROR1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 52.2 kDa and the accession number is A0A8I3MPB6. | |||
TMPK-00577 | ROR2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve... | |||
TMPK-00579 | ROR2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve... | |||
TMPK-00566 | ROR2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve... | |||
TMPK-00578 | ROR2 Protein, Human, Recombinant (aa 34-403, His & Avi), Biotinylated | Human | HEK293 Cells |
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve... | |||
TMPY-04649 | ROR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ROR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa and the accession number is Q01973. | |||
TMPY-05394 | ROR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ROR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.8 kDa and the accession number is Q01974. | |||
TMPY-06508 | ROR1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
ROR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 68.53 kDa and the accession number is NP_038873.2. | |||
TMPY-06850 | ROR2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
ROR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.64 kDa and the accession number is Q9Z138. | |||
TMPH-01792 | RORC Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
RORC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 74.2 kDa and the accession number is P51449. | |||
TMPH-00498 | Prorelaxin Protein, Canine, Recombinant (His) | Canine | E. coli |
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. Prorelaxin Protein, Canine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. Th... | |||
TMPY-06825 | ROR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells |
ROR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 70.53 kDa and the accession number is NP_005003.2. | |||
TMPY-04068 | ROR1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
ROR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69 kDa and the accession number is Q01973. | |||
TMPY-05603 | ROR1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
ROR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.2 kDa and the accession number is Q01973. | |||
TMPY-04428 | ROR1 Protein, Human, Recombinant (aa 453-783, His & GST) | Human | Baculovirus Insect Cells |
ROR1 Protein, Human, Recombinant (aa 453-783, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 65.3 kDa and the accession number is AAA60275.1. | |||
TMPY-05639 | ROR2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
ROR2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 44.6 kDa and the accession number is Q01974. | |||
TMPH-01791 | RORA Protein, Human, Recombinant (His) | Human | E. coli |
RORA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.6 kDa and the accession number is P35398. | |||
TMPY-04986 | ROR1 Protein, Human, Recombinant, Biotinylated | Human | HEK293 Cells |
ROR1 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 42.8 kDa and the accession number is Q01973. | |||
TMPY-06103 | ROR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
ROR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.3 kDa and the accession number is Q9Z139. | |||
TMPH-01241 | TOP1 Protein, Human, Recombinant (His & Myc) | Human | Baculovirus Insect Cells |
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran... |