Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ruzasvir (MK-8408) is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 44,000 | |||
5 mg | 在庫あり | ¥ 110,500 | |||
10 mg | 在庫あり | ¥ 158,000 | |||
25 mg | 在庫あり | ¥ 248,000 | |||
50 mg | 在庫あり | ¥ 340,000 |
説明 | Ruzasvir (MK-8408) is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity. |
In vitro | Ruzasvir (MK-8408) was developed as a novel NS5A inhibitor to improve upon the potency and barrier to resistance of early compounds. Ruzasvir inhibited HCV RNA replication with 50% effective concentrations (EC50s) of 1 to 4 pM in Huh7 or Huh7.5 cells bearing replicons for HCV genotype 1 (GT1) to GT7. The antiviral activity was modestly (10-fold) reduced in the presence of 40% normal human serum. The interaction of Ruzasvir with an NS3/4A protease inhibitor (grazoprevir) and an NS5B polymerase prodrug (uprifosbuvir) was additive to synergistic, with no evidence of antagonism or cytotoxicity.[1] |
別名 | MK8408, MK-8408, MK 8408 |
分子量 | 947.09 |
分子式 | C49H55FN10O7S |
CAS No. | 1613081-64-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (52.79 mM)
You can also refer to dose conversion for different animals. 詳細
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Ruzasvir 1613081-64-3 Microbiology/Virology Proteases/Proteasome HCV Protease MK8408 MK-8408 MK 8408 Inhibitor inhibitor inhibit