Powder: -20°C for 3 years | In solvent: -80°C for 1 year
STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705, which induces apoptosis and inhibits tumor cell growth and metastasis.STAT3-IN-13 can be used to study breast cancer and liver cancer. The study of breast cancer and hepatocellular carcinoma.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 75,500 | |||
10 mg | 在庫あり | ¥ 98,500 | |||
50 mg | 在庫あり | ¥ 206,000 | |||
100 mg | 在庫あり | ¥ 266,500 |
説明 | STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705, which induces apoptosis and inhibits tumor cell growth and metastasis.STAT3-IN-13 can be used to study breast cancer and liver cancer. The study of breast cancer and hepatocellular carcinoma. |
ターゲット&IC50 | MG63 cell:0.55 μM, 143B:0.25 μM, HOS:0.11 μM, STAT3:0.96 μM (Kd) |
In vitro | STAT3-IN-13 (compound 6f), over a period of 48 hours, demonstrates anti-proliferative activity with IC50 values of 0.25, 0.11, and 0.55 μM for 143B, HOS, and MG63 cells, respectively [1].In the concentration range of 0.001-100 μM, STAT3-IN-13 (compound 6f) binds to STAT3 and interacts with STAT3^586-685 in a concentration-dependent manner, with a KD of 0.96 μM [1].Over a period of 24 hours at concentrations ranging from 0 to 1.0 μM in 143B and HOS cells, STAT3-IN-13 (compound 6f) inhibits STAT3 Y705 phosphorylation and suppresses STAT3 in tumor cells [1].At concentrations ranging from 0 to 1.0 μM over 48 hours in 143B cells, STAT3-IN-13 (compound 6f) induces apoptosis in a dose-dependent manner [1]. |
In vivo | In vivo, STAT3-IN-13 (compound 6f), administered intraperitoneally at doses of 10-20 mg/kg twice daily for 4 weeks in nude mice, effectively blocks osteosarcoma growth and metastasis [1]. |
分子量 | 436.49 |
分子式 | C21H20N6O3S |
CAS No. | 2248552-86-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (183.28 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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STAT3-IN-13 2248552-86-3 JAK/STAT signaling Stem Cells STAT Inhibitor inhibitor inhibit