Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines[1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 32,000 | |||
5 mg | 在庫あり | ¥ 62,500 | |||
10 mg | 在庫あり | ¥ 98,500 | |||
25 mg | 在庫あり | ¥ 178,500 | |||
50 mg | 在庫あり | ¥ 257,000 | |||
100 mg | 在庫あり | ¥ 342,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 72,000 |
説明 | SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines[1]. |
In vitro | SC-1(1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells[1]. SC-1(1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity in association with downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines[1]. |
In vivo | SC-1 showes efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors in vivo[1]. |
細胞研究 | Incubated HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells with 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM SC-1 for 48 hours demonstrated that dose-dependent suppression of cell viability in all tested breast cancer cells[1]. Incubated HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells with 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM SC-1 for 36 hours showed downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines and induced potent apoptotic activity[1]. |
動物実験 | SC-1 (10 mg/kg; oral gavage; daily; for 28 days; Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors[1]. |
分子量 | 431.8 |
分子式 | C21H13ClF3N3O2 |
CAS No. | 1313019-65-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (127.37 mM)
You can also refer to dose conversion for different animals. 詳細
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