Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tallimustine HCl is a DNA inhibitor, an AT-specific alkylated antitumor derivative of diamycin.Tallimustine HCl can be used in severe combined immunodeficiency mouse models of adult myelogenous leukemia, which can be used for the treatment of leukemia.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 99,000 | |||
10 mg | 在庫あり | ¥ 146,000 | |||
25 mg | 在庫あり | ¥ 226,500 | |||
50 mg | 在庫あり | ¥ 312,500 | |||
100 mg | 在庫あり | ¥ 420,000 | |||
500 mg | 在庫あり | ¥ 844,500 |
説明 | Tallimustine HCl is a DNA inhibitor, an AT-specific alkylated antitumor derivative of diamycin.Tallimustine HCl can be used in severe combined immunodeficiency mouse models of adult myelogenous leukemia, which can be used for the treatment of leukemia. |
ターゲット&IC50 | CEM cells:3.5 nM |
In vitro |
Tallimustine HCl (0.1-10 μM; 4 h) causes harm to isolated SV40 DNA. Additionally, Tallimustine HCl exhibits cytotoxicity in CEM cells after 72 hours, displaying an IC50 of 3.5 nM.[1] Tallimustine HCl (25 and 100 nM, 6 days) induces erythroid differentiation of K562 cells.[2] Tallimustine HCl (100 nM, 6 days) increases accumulation of γ-globin mRNA in K562 cells.[2] Tallimustine HCl (0.5 μg/mL, 1 h) arrests SW626 cells in G2/M phase.[3] |
In vivo | Tallimustine HCl (3 mg/kg; i.p.; ) prolonged survival and shows antileukemic activity in L1210 tumor-bearing mice and.[4] |
別名 | Tallimustine HCl(115308-98-0 Free base) |
分子量 | 734.08 |
分子式 | C32H39Cl3N10O4 |
CAS No. | 118438-45-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (61.3 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tallimustine HCl 118438-45-2 DNA Damage/DNA Repair DNA Tallimustine HCl(115308-98-0 Free base) Inhibitor inhibitor inhibit