Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50= 195 nM). TDI-10229 exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.
説明 | TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50= 195 nM). TDI-10229 exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound. |
In vitro | TDI-10229 inhibits human 4-4 cells with an IC50 of 92 nM for[2]. |
In vivo | TDI-10229 (20 mg/kg; p.o.) treatment in mouse shows the AUC, Cmax, and MRT were 94 μg h/mL, 15.5 μM, and 3.95 hours, respectively[2]. |
分子量 | 313.78 |
分子式 | C16H16ClN5 |
CAS No. | 2810887-45-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (358.5 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TDI-10229 2810887-45-5 GPCR/G Protein cAMP TDI10229 CompoundTDI10229 TDI 10229 Inhibitor inhibitor inhibit