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Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitumor activity.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 85,500 |
5 mg | 在庫あり | ¥ 214,500 |
10 mg | 在庫あり | ¥ 342,000 |
25 mg | 在庫あり | ¥ 503,000 |
50 mg | 在庫あり | ¥ 682,000 |
100 mg | 在庫あり | ¥ 902,000 |
説明 | Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitumor activity. |
In vitro | Telisotuzumab (ABT-700) (10 μg/mL; 24 h) can inhibit the proliferation of SNU5 cells and lead to an increase in pro-apoptotic Bim and a decrease in anti-apoptotic Bcl-xL, thereby inducing apoptosis.[1] |
In vivo | Telisotuzumab (ABT-700) (2.5-40 mg/kg; i.p.; twice a week; 90 days) potently antagonizes constitutively activated c-Met and downstream signaling, thereby inhibiting tumor growth in Hs746T cell-derived SCID mice.[1] |
別名 | ABT-700, Mab-224G11 |
分子量 | N/A |
CAS No. | 1781223-80-0 |
store at low temperature
store at -20°C
You can also refer to dose conversion for different animals. 詳細
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Telisotuzumab 1781223-80-0 Tyrosine Kinase/Adaptors c-Met/HGFR ABT-700 Mab-224G11 ABT 700 ABT700 Inhibitor inhibitor inhibit