Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Savolitinib (Volitinib) (AZD-6094) is an effective, selective, and orally bioavailable c-Met inhibitor (IC50s: 5 nM/3 nM for c-Met/p-Met).
説明 | Savolitinib (Volitinib) (AZD-6094) is an effective, selective, and orally bioavailable c-Met inhibitor (IC50s: 5 nM/3 nM for c-Met/p-Met). |
ターゲット&IC50 | p-Met:3 nM (cell free), c-Met:5 nM (cell free) |
In vitro | Savolitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways [1,2]. |
In vivo | In a U87MG subcutaneous xenograft model, Savolitinib (1-10.0 mg/kg; oral administration; daily; for 21 days; athymic nude mice) demonstrates dose-dependent tumor growth inhibition. In addition, none of the mice in the dosing groups exhibits body weight loss during the experiment [1]. |
別名 | AZD-6094, Volitinib, HMPL-504 |
分子量 | 345.36 |
分子式 | C17H15N9 |
CAS No. | 1313725-88-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32 mg/mL (92.65 mM)
You can also refer to dose conversion for different animals. 詳細
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Savolitinib 1313725-88-0 Tyrosine Kinase/Adaptors c-Met/HGFR inhibit Inhibitor AZD6094 AZD-6094 HMPL 504 Volitinib HMPL504 AZD 6094 HMPL-504 inhibitor