Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with IC50 value of 12 μM. ThioLox shows anti-inflammatory and neuroprotective properties. It has anti-inflammatory and neuroprotective effects, and has a strong protective effect against glutamate toxicity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 14,000 | |||
5 mg | 在庫あり | ¥ 34,000 | |||
10 mg | 在庫あり | ¥ 52,500 | |||
25 mg | 在庫あり | ¥ 98,500 | |||
50 mg | 在庫あり | ¥ 147,000 | |||
100 mg | 在庫あり | ¥ 204,500 | |||
500 mg | 在庫あり | ¥ 420,000 |
説明 | ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with IC50 value of 12 μM. ThioLox shows anti-inflammatory and neuroprotective properties. It has anti-inflammatory and neuroprotective effects, and has a strong protective effect against glutamate toxicity. |
ターゲット&IC50 | 15-LOX1:3.3 (Ki) |
In vitro | ThioLox (50 μM; 24 h) inhibits the expression of interleukins (IL-1β, IL-6, IL-8, IL-12b, TNFα, and iNOS) in precision-cut lung slices (PCLS). In neuronal cells, ThioLox (10 μM; 16 h) prevents mitochondrial superoxide formation and lipid peroxidation. ThioLox (5-20 μM; 14-16 h) prevents HT-22 cells from glutamate toxicity. ThioLox significantly reduces neuronal cell death[1]. |
In vivo | The logP value of ThioLox is 3, indicating that it is predicted to effectively penetrate the blood-brain barrier[1]. |
分子量 | 274.38 |
分子式 | C15H18N2OS |
CAS No. | 1202193-89-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (328.0 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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ThioLox 1202193-89-2 Metabolism Lipoxygenase Inhibitor inhibitor inhibit