Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 7,000 | |||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 74,000 | |||
100 mg | 在庫あり | ¥ 118,000 |
説明 | S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity. |
In vitro | Marmesin treatment abrogated VEGF-A-induced endothelial cell migration, invasion and capillary-like structure formation in vitro as well as angiogenic sprouting ex vivo. These anti-angiogenic activities of marmesin were mediated through inactivation of VEGF-A-stimulated signaling pathways, and down-regulation of cell surface signaling molecules including VEGF receptor-2, human epidermal growth factor receptor-2, integrin β1 and integrin-liked kinase[1]. |
In vivo | Marmesin inhibits colony formation and induces apoptosis dose-dependently.Marmesin treatment triggered upregulation of Bax and downregulation of Bcl-2 causing significant increase in the Bax/Bcl-2 ratio, marmesin could also induce ROS mediated alterations in mitochondrial membrane potential. Additionally, marmesin induced G2/M cell cycle arrest and significantly inhibited cell migration potential of leukemia cells at the IC50. Remarkably, marmesin prevent tumor growth significantly in vivo at the dosage of 30 mg/kg in vivo. These results strongly indicate that marmesin may prove to be a novel anticancer lead for the management of leukemia[2]. |
別名 | (+)-Marmesin, (S)-Marmesin, marmesin |
分子量 | 246.26 |
分子式 | C14H14O4 |
CAS No. | 13849-08-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2 mg/mL (8.12 mM)
You can also refer to dose conversion for different animals. 詳細
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S-(+)-Marmesin 13849-08-6 Immunology/Inflammation Metabolism Neuroscience COX Lipoxygenase S-Marmesin (+)-Marmesin LOX (S)-Marmesin S(+)Marmesin Cyclooxygenase inhibit marmesin Inhibitor S (+) Marmesin inhibitor