Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 67,500 |
5 mg | 在庫あり | ¥ 166,000 |
10 mg | 在庫あり | ¥ 226,500 |
25 mg | 在庫あり | ¥ 349,000 |
50 mg | 在庫あり | ¥ 454,500 |
説明 | Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase. |
ターゲット&IC50 | HepG2:1.54 µM, SW480:37.53 µM, Hela:24.61 µM, MDA-MB-231:11.41 µM |
In vitro | In HepG2, SW480, Hela, and MDA-MB-231 cells, Tubulin inhibitor 32 (0-64 µM; 48 hours) exhibited anti-proliferative activity, with IC50 values of 1.54, 37.53, 24.61, and 11.41 µM, respectively[1]. |
In vivo | In 4-6 weeks old male nude mice (HCT-116 tumor model), Tubulin inhibitor 32 (50, 100 mg/kg; oral administration; once daily for 20 days) decreased the tumor volume and tumor weight by 44.1% and 27.0%, respectively[1]. |
分子量 | 325.36 |
分子式 | C18H19N3O3 |
CAS No. | 2923531-39-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Tubulin inhibitor 32 2923531-39-7 Apoptosis Inhibitor inhibitor inhibit