Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type. It demonstrates notable antiproliferative effects on Ba/F3 cells expressing CD74-TRKA G667C and ETV6-TRKC G696C, with half-maximal inhibitory concentrations (IC50s) of 6 nM and 1.7 nM, respectively [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | お問い合わせ | ¥ 314,500 |
50 mg | お問い合わせ | ¥ 638,000 |
100 mg | お問い合わせ | ¥ 849,500 |
説明 | Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type. It demonstrates notable antiproliferative effects on Ba/F3 cells expressing CD74-TRKA G667C and ETV6-TRKC G696C, with half-maximal inhibitory concentrations (IC50s) of 6 nM and 1.7 nM, respectively [1]. |
In vitro | Type II TRK inhibitor 1 (compound 7b) at concentrations ranging from 3.1 to 800 nM and a 2-hour incubation period inhibits the phosphorylation of TRKA, PLCγ1, and ERK [1]. |
分子量 | 670.68 |
分子式 | C35H33F3N8O3 |
CAS No. | 2937543-72-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Type II TRK inhibitor 1 2937543-72-9 Tyrosine Kinase/Adaptors Trk receptor Inhibitor inhibitor inhibit