Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pass through prefabricated hTNF/hTNFR1 complexes.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 103,500 | |||
50 mg | 在庫あり | ¥ 152,500 | |||
100 mg | 在庫あり | ¥ 217,000 | |||
500 mg | 在庫あり | ¥ 431,500 |
説明 | UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pass through prefabricated hTNF/hTNFR1 complexes. |
ターゲット&IC50 | TNF-α:9 nM(KD) |
In vitro |
UCB-5307 exhibits inhibition against wild-type TNF but does not inhibition against L57F TNF. The half-life of UCB-5307 is determined to be 3.3 hours.[1] UCB-5307 disrupts a preexisting complex between hTNF and hTNFR1, penetrating the complex and displacing one of the receptors. Prior exposure of hTNF to UCB-5307 prevents one receptor from binding.[1] |
分子量 | 343.42 |
分子式 | C22H21N3O |
CAS No. | 1515887-44-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (131.0 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
UCB-5307 1515887-44-1 Apoptosis TNF Inhibitor inhibitor inhibit