store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates without significantly perturbing levels of other inositol phosphates. UNC7467 can be used for obesity research [1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,000 | |||
5 mg | 在庫あり | ¥ 17,000 | |||
10 mg | 在庫あり | ¥ 27,000 | |||
25 mg | 在庫あり | ¥ 63,000 | |||
50 mg | 在庫あり | ¥ 91,000 | |||
100 mg | 在庫あり | ¥ 131,500 | |||
500 mg | 在庫あり | ¥ 264,000 |
説明 | UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates without significantly perturbing levels of other inositol phosphates. UNC7467 can be used for obesity research [1]. |
In vitro | UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces inositol pyrophosphates levels. UNC7467 reduces 5-InsP 7 levels by 81% and 5-InsP 8 levels by 63% [1]. |
In vivo | UNC7467, administered at a dosage of 5 mg/kg through intraperitoneal injection daily for 4 weeks, significantly ameliorated diet-induced obesity, insulin resistance, and hepatic steatosis in mice with diet-induced obesity (DIO). This compound also demonstrated considerable pharmacokinetic benefits in DIO mice, presenting a low clearance rate of 13.7 (mL/min)/kg and yielding substantial area under the curve (AUC) values of 6054 h ng/mL for intravenous (i.v.) and 2527 h ng/mL for intraperitoneal (i.p.) routes at a 5 mg/kg dose. Furthermore, it improved glycemic profiles, mitigated hepatic steatosis, and curbed weight gain without affecting the mice's food intake. These findings underscore UNC7467's potential as an efficacious agent for treating diet-induced obesity and related metabolic disorders. |
分子量 | 315.32 |
分子式 | C20H13NO3 |
CAS No. | 2922283-43-8 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.15 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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UNC7467 2922283-43-8 Others UNC 7467 UNC-7467 Inhibitor inhibitor inhibit