Powder: -20°C for 3 years | In solvent: -80°C for 1 year
XST-14 is a competitive and specific inhibitor of ULK1 (IC50: 26.6 nM).XST-14 blocks autophagy by inhibiting the phosphorylation of ULK1 downstream substrates.XST-14 induces apoptosis and inhibits the growth of HCC cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 31,000 | |||
5 mg | 在庫あり | ¥ 75,500 | |||
10 mg | 在庫あり | ¥ 112,500 | |||
25 mg | 在庫あり | ¥ 180,500 | |||
50 mg | 在庫あり | ¥ 257,000 | |||
100 mg | 在庫あり | ¥ 369,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 52,000 |
説明 | XST-14 is a competitive and specific inhibitor of ULK1 (IC50: 26.6 nM).XST-14 blocks autophagy by inhibiting the phosphorylation of ULK1 downstream substrates.XST-14 induces apoptosis and inhibits the growth of HCC cells. |
ターゲット&IC50 | ULK1:26.6 nM |
In vitro | Treatment of HepG2 cells with XST-14 (5 μM) alone or in combination with sorafenib (5 μM) for 24 hours showed a synergistic effect, indicating that XST-14 in combination with sorafenib can inhibit HCC in vitro[1]. |
In vivo | BALB/c mice were treated with XST-14 (30 mg/kg, IP, every other day), sorafenib (30 mg/kg, P.O), or a combination of sorafenib (30 mg/kg, P.O) and XST-14 (30 mg/kg, IP) for 2 weeks. The results indicate that XST-14 exhibits favorable drug metabolism and pharmacokinetic (DMPK) properties, with no significant toxicity observed on liver/kidney function or body weight. |
分子量 | 291.34 |
分子式 | C16H21NO4 |
CAS No. | 2607143-50-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (274.59 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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XST-14 2607143-50-8 Apoptosis Autophagy Inhibitor inhibitor inhibit