Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder contraction in rats by inhibiting bladder pressurization. YM-58790 free base inhibits reflex rhythmic bladder contractions in rats by inhibiting bladder pressurization.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 34,000 | |||
5 mg | 在庫あり | ¥ 74,500 | |||
10 mg | 在庫あり | ¥ 118,500 | |||
25 mg | 在庫あり | ¥ 227,500 | |||
50 mg | 在庫あり | ¥ 385,500 | |||
100 mg | 在庫あり | ¥ 619,500 | |||
500 mg | 在庫あり | ¥ 867,500 |
説明 | YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder contraction in rats by inhibiting bladder pressurization. YM-58790 free base inhibits reflex rhythmic bladder contractions in rats by inhibiting bladder pressurization. |
ターゲット&IC50 | M2 mAChR:260 nM (Ki), M1 mAChR:28 nM (Ki), M3 mAChR:15 nM (Ki) |
In vitro | YM-58790 free base (compound 18b) (0-1 μM) exerts a potent inhibitory effect on urinary bladder contraction while having minimal impact on bradycardia. In vitro, YM-58790 demonstrates selective antagonism between urinary bladder contraction and salivary secretion.[1] |
In vivo |
YM-58790 free base (3 mg/kg, i.v.) exhibits no impact on oxotremorine-induced tremor in mice.[1] YM-58790 free base (6.0 mg/kg; i.v.) exhibits limited M1 and M2 antagonistic effects in vivo on McN-A343-induced pressor response in pithed rats. However, it demonstrates robust efficacy in M3 antagonism, with an ED30 value of 0.36 mg/kg and an ID50 value of 2.4 mg/kg.[1] YM-58790 free base demonstrates robust inhibitory activity on bladder pressure during reflexly-evoked rhythmic contractions in rats.[1] |
別名 | YM-58790 free base |
分子量 | 429.55 |
分子式 | C27H31N3O2 |
CAS No. | 168830-70-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (139.68 mM)
You can also refer to dose conversion for different animals. 詳細
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YM-58790 168830-70-4 Neuroscience AChR YM-58790 free base YM 58790 YM58790 Inhibitor inhibitor inhibit