Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zoniporide hydrochloride is a selective inhibitor of NHE-1 with IC50 of 14 nM which is >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride shows an IC50 of 59 nM for NHE-1-dependent swelling of human platelets.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 13,000 | |||
5 mg | 在庫あり | ¥ 29,500 | |||
10 mg | 在庫あり | ¥ 42,500 | |||
25 mg | 在庫あり | ¥ 72,500 |
説明 | Zoniporide hydrochloride is a selective inhibitor of NHE-1 with IC50 of 14 nM which is >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride shows an IC50 of 59 nM for NHE-1-dependent swelling of human platelets. |
In vivo | In rats, Zoniporide hydrochloride (1 mg/kg; i.v.) shows the AUC0-∞ and t1/2 are 0.07 μg h/mL and 0.5 hours, respectively[1]. In open chest anesthetized rabbits, Zoniporide hydrochloride (0.25, 1, 4 mg/kg; i.v.) dose-dependently reduces infarct size with an ED50 of 0.45 mg/kg/h. Zoniporide hydrochloride exhibits moderate plasma protein binding with t1/2 of 1.5h in monkeys[2]. |
別名 | CP-597396 hydrochloride |
分子量 | 356.81 |
分子式 | C17H17ClN6O |
CAS No. | 241800-97-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. 詳細
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Zoniporide hydrochloride 241800-97-5 Membrane transporter/Ion channel Sodium Channel CP 597396 Hydrochloride Zoniporide Hydrochloride CP-597396 Hydrochloride CP-597396 hydrochloride CP597396 Hydrochloride Inhibitor inhibitor inhibit