Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes. Examination of the different signaling cascades induced by RTKs established Ras/MAPK, PI3K, and phospholipase-γ (PLCγ) pathways as key downstream mediators of PDGFR signaling. In addition, reactive oxygen species (ROS)-dependent STAT3 activation has been established to be a key downstream mediator of PDGFR signaling in vascular smooth muscle cells.
カタログ番号 | 製品名 / Synonyms | Species | Expression System |
---|---|---|---|
TMPY-01139 | PDGFRA Protein, Human, Recombinant (His)
PDGFRA Protein, Human, Recombinant (His)
|
Human | HEK293 |
PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived grow... | |||
TMPY-06921 | PDGFRA Protein, Cynomolgus, Recombinant (His)
PDGFRA Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 |
PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived grow... | |||
TMPY-05789 | PDGFRA Protein, Mouse, Recombinant (hFc)
PDGFRA Protein, Mouse, Recombinant (hFc)
|
Mouse | HEK293 |
PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived grow... | |||
TMPY-05787 | PDGFRA Protein, Mouse, Recombinant (His)
PDGFRA Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived grow... | |||
TMPY-05608 | PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived grow... | |||
TMPY-05497 | PDGFRB Protein, Human, Recombinant (hFc)
PDGFRB Protein, Human, Recombinant (hFc)
|
Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-05358 | PDGFRB Protein, Human, Recombinant
PDGFRB Protein, Human, Recombinant
|
Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-04937 | PDGFRB Protein, Human, Recombinant (His), Biotinylated
PDGFRB Protein, Human, Recombinant (His), Biotinylated
|
Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-03919 | PDGFRA Protein, Rat, Recombinant (hFc)
PDGFRA Protein, Rat, Recombinant (hFc)
|
Rat | HEK293 |
PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived grow... | |||
TMPY-03825 | PDGFRA Protein, Rat, Recombinant (His)
PDGFRA Protein, Rat, Recombinant (His)
|
Rat | HEK293 |
PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived grow... | |||
TMPY-03590 | PDGFRB Protein, Rhesus, Recombinant (His)
PDGFRB Protein, Rhesus, Recombinant (His)
|
Rhesus | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-03474 | PDGFRB Protein, Rat, Recombinant (hFc)
PDGFRB Protein, Rat, Recombinant (hFc)
|
Rat | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-03140 | PDGFRB Protein, Rat, Recombinant (His)
PDGFRB Protein, Rat, Recombinant (His)
|
Rat | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-01207 | PDGFRB Protein, Human, Recombinant (His)
PDGFRB Protein, Human, Recombinant (His)
|
Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-00900 | PDGFRA Protein, Human, Recombinant (hFc)
PDGFRA Protein, Human, Recombinant (hFc)
|
Human | HEK293 |
PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived grow... | |||
TMPY-00385 | PDGFRB Protein, Rhesus, Recombinant (hFc)
PDGFRB Protein, Rhesus, Recombinant (hFc)
|
Rhesus | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPK-01050 | PDGF R beta/CD140b Protein, Canine, Recombinant (His)
PDGF R beta/CD140b Protein, Canine, Recombinant (His)
|
Canine | HEK293 |
PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and... | |||
TMPK-00943 | PDGF R alpha/PDGFRA Protein, Cynomolgus, Recombinant (His)
PDGF R alpha/PDGFRA Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 |
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. Th... | |||
TMPK-00481 | PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)
PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 |
Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β s... | |||
TMPK-00422 | PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated
PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and... |