Myelin protein zero-like protein 1(MPZL1) is encoded by the MPZL1 gene, which is a single-pass type I membrane protein. It is widely expressed with highest levels in heart, placenta, kidney and pancreas. As cell surface receptor, it involved in signal transduction processes. MPZL1 recruits PTPN11/SHP-2 to the cell membrane and subsequently activate/phosphorylate Src kinase at Tyr426, promoting phosphorylation of cortactin and migration of HCC cells. MPZL1also is a major receptor for concanavalin-A (ConA) and involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 μg | 約5 days | ¥ 14,000 |
50 μg | 約5 days | ¥ 30,000 |
500 μg | 約5 days | ¥ 185,000 |
1 mg | 約5 days | ¥ 298,500 |
説明 | Myelin protein zero-like protein 1(MPZL1) is encoded by the MPZL1 gene, which is a single-pass type I membrane protein. It is widely expressed with highest levels in heart, placenta, kidney and pancreas. As cell surface receptor, it involved in signal transduction processes. MPZL1 recruits PTPN11/SHP-2 to the cell membrane and subsequently activate/phosphorylate Src kinase at Tyr426, promoting phosphorylation of cortactin and migration of HCC cells. MPZL1also is a major receptor for concanavalin-A (ConA) and involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | C-6xHis |
Accession Number | O95297 |
別名 | FLJ96614, mRNA, Myelin protein zero-like 1, cDNA FLJ78597, cDNA, Homo sapiens myelin protein zero-like 1 (MPZL1), isoform CRA_b, highly similar to Homo sapiens myelin protein zero-like 1 (MPZL1), transcript variant 1 |
Amino Acid | Ser36-Val162 |
Construction | Ser36-Val162 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 20-28 KDa (reducing condition) |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Myelin protein zero-like protein 1(MPZL1) is encoded by the MPZL1 gene, which is a single-pass type I membrane protein. It is widely expressed with highest levels in heart, placenta, kidney and pancreas. As cell surface receptor, it involved in signal transduction processes. MPZL1 recruits PTPN11/SHP-2 to the cell membrane and subsequently activate/phosphorylate Src kinase at Tyr426, promoting phosphorylation of cortactin and migration of HCC cells. MPZL1also is a major receptor for concanavalin-A (ConA) and involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. |
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Please read the User Guide of Recombinant Proteins for more specific information.
MPZL1 Protein, Human, Recombinant (His) cDNA FLJ-78597 MPZL1 FLJ96614 FLJ-96614 mRNA Myelin protein zero-like 1 cDNA FLJ78597 cDNA FLJ 78597 cDNA Homo sapiens myelin protein zero-like 1 (MPZL1) Homo sapiens myelin protein zero-like 1 FLJ 96614 isoform CRA_b MPZL 1 highly similar to Homo sapiens myelin protein zero-like 1 (MPZL1) transcript variant 1 MPZL-1 recombinant recombinant-proteins proteins protein