TNF RII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is P20333.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 μg | 約5 days | ¥ 27,000 |
50 μg | 約5 days | ¥ 71,500 |
500 μg | 約5 days | ¥ 436,000 |
1 mg | 約5 days | ¥ 626,500 |
説明 | TNF RII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is P20333. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | C-hFc |
Accession Number | P20333 |
別名 | TNF-R2, Tumor necrosis factor receptor superfamily member 1B, TNF-RII, TNFRSF1B, Tumor necrosis factor receptor 2, p75, p80 TNF-α receptor, p80 TNF-alpha receptor, CD120b, Tumor necrosis factor receptor type II |
Amino Acid | Leu23-Asp257 |
Construction | Leu23-Asp257 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 60-90 KDa (reducing condition) |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs, respectively.TNF RII is expressed predominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as on endothelial cells, microglia, astrocytes,neurons, oligodendrocytes, cardiac myocytes, thymocytes, and mesenchymal stem cells.TNF RII binds to the membranebound forms of TNFα and Lymphotoxinα/TNFβ;soluble TNF is thought to signal predominately through TNF RI.Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors. |
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Please read the User Guide of Recombinant Proteins for more specific information.
TNF RII Protein, Human, Recombinant (hFc) TNF-R2 Tumor necrosis factor receptor superfamily member 1B TNF-RII TNFRSF1B Tumor necrosis factor receptor 2 p75 p80 TNF-α receptor p80 TNF-alpha receptor p80 TNF-a receptor CD120b Tumor necrosis factor receptor type II recombinant recombinant-proteins proteins protein