TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)

Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction.

TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 138,000

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説明

Species	Human
Expression Host	E. coli
Tag	His
Accession Number	Q16881-1
別名	thioredoxin reductase 1, TR1, TXNR, TR, TRXR1, GRIM-12
Construction	A DNA sequence encoding the human TXNRD1 isoform 1 (Q16881-1) (Tyr 161-Cys 647) was expressed, with a polyhistide tag at the N-terminus.
Protein Purity	> 90 % as determined by SDS-PAGE
分子量	55 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction.

参考文献

1. Gasdaska P.Y., et al., 1995, FEBS Lett. 373:5-9. 2. Rundloef A.-K., et al., 2004, Free Radic. Biol. Med. 36:641-656. 3. Rikova K., et al., 2007, Cell 131:1190-1203. 4. Fritz-Wolf K., et al., 2007, J. Mol. Biol. 370:116-127. 5. Choudhary C., et al., 2009, Science 325:834-840.

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TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)

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